Canonical Transient Receptor Potential ( TRPC ) 1 Acts as a Negative Regulator for Vanilloid TRPV 6 - mediated Ca 2
نویسندگان
چکیده
Rainer Schindl, Reinhard Fritsch, Isaac Jardin, Irene Frischauf, Heike Kahr, Martin Muik, Maria Christine Riedl, Klaus Groschner , and Christoph Romanin From the Institute for Biophysics, University of Linz, A-4020 Linz, Austria, the Institute of Pharmacology and Toxicology, University of Graz, A-8010 Graz, Austria, the Department of Physiology, University of Extremadura, 10003 Caceres, Spain, and the School of Engineering/Enviromental/Sciences, University of Applied Sciences Upper Austria, A-4600 Wels, Austria
منابع مشابه
Pharmacology of vanilloid transient receptor potential cation channels.
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ("Mucolipin"), and TRPA ("Ankyrin"). The TRPV subfamily (vanilloid receptors) comprises channels critically involved in nociception and thermosensing (...
متن کاملCanonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca2+ Influx*
TRP proteins mostly assemble to homomeric channels but can also heteromerize, preferentially within their subfamilies. The TRPC1 protein is the most versatile member and forms various TRPC channel combinations but also unique channels with the distantly related TRPP2 and TRPV4. We show here a novel cross-family interaction between TRPC1 and TRPV6, a Ca(2+) selective member of the vanilloid TRP ...
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The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-...
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Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca(2+) enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca(2+) channels. They are thus similar to K(V) (voltage-ga...
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TRP (transient receptor potential) channels respond to a plethora of stimuli in a fine-tuned manner. We show here that both membrane potential and the level of PI (phosphatidylinositol) phosphates are efficient regulators of TRP channel gating. Recent work has shown that this regulation applies to several members of the TRPV (TRP vanilloid) subfamily (TRPV1 and TRPV5) and the TRPM (TRP melastat...
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